Champions Manchester City fell eight points behind Liverpool in the title race after suffering a shock home defeat against Wolves.
Adama Traore scored twice in the final 10 minutes as Wolves won in the top flight at Manchester City for the first time since 1979.
Traore scored the first 10 minutes from time as the visitors capitalised on a mistake from Joao Cancelo. He added a second on the break deep into injury time.
Tammy Abraham scored his eighth league goal of the season as in-form Chelsea swept aside Southampton at St Mary’s to climb to fifth in the Premier League.
Chelsea dominated from the outset and took the lead when Abraham’s looping finish from Callum Hudson-Odoi’s pass was adjudged to have crossed the line before Maya Yoshida’s intervention.
Mason Mount doubled the Blues’ lead from close range, before Danny Ings poked home Yan Valery’s cut-back to reduce the arrears.