Real Madrid manager, Zinedine Zidane, will be without Ronaldo, Kroos, Marceloor Sunday’s trip to in-form Real Sociedad.
Ronaldo, who scored twice in midweek against APOEL Nicosia in the Champions League, is still banned from domestic fixtures.
Kroos missed training on Saturday, with a minor muscle problem and joins the suspended Ronaldo and Marcelo and injured Karim Benzema, Mateo Kovacic and Jesus Vallejo on the sidelines.
“Toni has felt discomfort and we are not going to risk anything,” Zidane said on Saturday.
“In the course of the season there are complicated moments and that’s what we have now with injuries.”
Real already trail rivals Barcelona by four points in the La Liga title race after just three games.
Sociedad are level with Barca at the top of the table, after their best start to a league season since 1981.